Mechanochemical hydroquinone regeneration promotes gold salt reduction in sub-stoichiometric conditions of the reducing agent.

Bottom-up mechanochemical synthesis (BUMS) has been demonstrated to be an efficient approach for the preparation of metal nanoparticles (NPs), protected by surface agents or anchored on solid supports. However, there are limitations, such as precise size and morphological control, due to a lack of knowledge about the mechanically induced processes of NP formation under milling. In this article, we further investigate the BUMS of AuNPs. Using SiO2 as a solid support, we studied the effect of typical reducing agents, namely NaBH4, L-ascorbic acid, and hydroquinone (HQ), on the conversion of a AuIII source. XANES showed that HQ is the strongest reducing agent under our experimental conditions, leading to the quantitative conversion of gold salt in a few minutes. Interestingly, even when HQ was used in sub-stoichiometric amounts, AuIII could be reduced to ratios higher than 85% after two minutes of milling. Investigations into the byproducts by 1H NMR and GC-FID/MS enabled the identification HQ regeneration and the formation of its derivatives. We mainly focused on benzoquinone (BQ), which is the product of the oxidation of HQ as it reduces the gold salt. We could demonstrate that HQ is regenerated from BQ exclusively under milling and acidic conditions. The regenerated HQ and other HQ-chlorinated molecules could then reduce gold-oxidized species, leading to higher conversions and economy of reactants. Our study highlights the intriguing and complex mechanisms of mechanochemical systems, in addition to fostering the atom and energy economy side of mechanochemical means to produce metal nanoparticles.

Functionality and loneliness in older people: Model of mediation by positive affect / Funcionalidad y soledad en personas mayores: Modelo de mediación por el afecto positivo

Objetivo: La soledad se asocia a la discapacidad funcional en la población mayor, aunque se sabe poco sobre el papel de la afectividad en esta relación. Nos proponemos explorar el efecto mediador de la afectividad en la relación entre funcionalidad y soledad, controlando el efecto de las variables relevantes. Métodos: Se administró la Escala de Soledad de la Universidad de California-16, la Escala de Funcionalidad Geriátrica, las Escalas de Afecto Positivo y Negativo-14 y la Escala de Depresión Geriátrica-8 a 489 adultos mayores (65–100 años), 428 de residencias geriátricas y 61 de la comunidad. Resultados: Los residentes en una institución, mujeres, viudos, con baja educación, más discapacidad funcional, más afecto negativo, menos afecto positivo y más síntomas depresivos reportaron más soledad. Controlando el efecto de los síntomas depresivos, género, situación residencial, estado civil y educación, solo el afecto positivo medió, parcialmente, la relación entre funcionalidad y soledad. Conclusión: Se sugieren intervenciones para aumentar la concienciación por parte de los adultos mayores en los perfiles personalizados de afecto positivo, aliviando así los sentimientos de soledad en los que sufren limitaciones funcionales (especialmente mujeres, con síntomas depresivos, viudos, residiendo en una institución y con bajo nivel educativo).(AU)

Objective: Research has shown that loneliness is associated with functional disability in the older population. However, little is known about the role of affectivity in this relationship. The present study explored a mediation model in which affectivity was hypothesized to mediate the re-lationship between functionality and loneliness, controlling for the effect of relevant variables.Methods:The University of California Loneliness Scale-16 items, Geriatric Functionality Scale, Positive and Negative AffectSchedule-14, and Geriatric Depression Scale-8 were administered to 489 old adults (65–100 years old), 428 from social care homes (SCH), and 61 from the community.Results:Those from SCH, women, widowed, withlow education, more functional disability, more negative affect, less posi-tive affect, and more depressive symptoms reported more loneliness. Con-trolling for the effect of depressive symptoms, gender, residential status, marital status, and education, only positive affect mediated, partially, the relationship between functionality and loneliness.Conclusion:We suggest implementing interventions that increase older adults' insights in personal-ized patterns of positive affect and, consequently, ease feelings of loneli-ness in older people suffering from functional limitations (especially wom-en, with depressive symptoms, widowed, residing in an institution, and with low educational level).(AU)

Mini-ACE: Validation Study Among Older People in Long-Term Care.

Background: The Mini-Addenbrooke's Cognitive Examination (M-ACE) is a valid and reliable tool that accurately differentiates various types of cognitive impairment from Normal-cognition assessed in multiple settings. However, its validity among older individuals in long-term care (LTC) was not yet established. Therefore, we sought to assess the Portuguese M-ACE's validity, reliability, and accuracy in detecting cognitive impairment no-dementia (CIND) in LTC users. Methods: A comprehensive assessment was performed on 196 LTC Portuguese users aged ≥ 60 years, among whom 71 had Normal-cognition, and 125 had CIND. Results: The M-ACE was found to be reliable (McDonald's ω = .86, Cronbach's α = .85) and consistent over time (r = .72; ICC = .83) and between raters (k = .92). Strong correlations with related measures supported construct validity (both r = .67). The M-ACE accurately distinguished CIND from Normal-cognition with a cut-off of 17 points (AUC = 0.81, Sensitivity = 81.7%, Specificity = 74.4%). Conclusion: Our findings suggest that the Portuguese M-ACE is a valid and reliable cognitive assessment tool for LTC users, allowing for accurate differentiation between CIND and Normal-cognition. Thus, the M-ACE's use could contribute to the early detection and intervention of cognitive disorders, especially among older adults in LTC.

Emotion dysregulation in older people: validity and reliability of an 8-item version of the Difficulties in Emotion Regulation Scale.

OBJECTIVES: The abbreviated 16-item version of the Difficulties with Emotion Regulation Scale (DERS-16) is widely used to assess individuals' perceived challenges in regulating their emotions, a central aspect of psychological symptoms commonly experienced in old age. However, its psychometric properties have yet to be tested in this population. Furthermore, a shorter version of the DERS-16 could further minimize the assessment burden on older individuals. Thus, we aimed to test the DERS-16's psychometric performance and determine if any items were redundant to develop a psychometrically sound shorter version. METHODS: We enrolled 302 Portuguese older adults (Mage = 75.22; SD = 8.99 years) in a cross-sectional study. RESULTS: Exploratory factor analyses indicated a one-factor structure and a four-factor solution with eight items (69.3%-81.9% of the variance observed). The four-factor-8-item solution presented an interpretable structure and demonstrated good reliability values (> 0.70) and construct validity with the Twenty-Item Toronto Alexithymia Scale, Eight-Item Geriatric Depression Scale, and Geriatric Anxiety Inventory (r = 0.66, 0.40, 0.52; p < 0.001). CONCLUSION: The robust psychometric properties of DERS-8 make it a valuable tool for clinical and longitudinal studies, facilitating targeted interventions in older adults and allowing for precise emotion dysregulation screening.

Measuring loneliness: Psychometric properties of the three-item loneliness scale among community-dwelling adults.

Loneliness is a prevalent set of negative feelings associated with unsatisfactory and reduced social interactions, inadequate social support, poor satisfaction with life and health, negative emotions, and economic burden. Thus, its measurement is of foremost importance. Therefore, this study aimed (i) to devise the Portuguese version of the three-Item Loneliness Scale (T-ILS), which is ideal for epidemiological studies, and (ii) to evaluate its psychometric properties. Three hundred forty-five community-dwelling Portuguese adults with a mean age of 54.6 ± 19.5 years, 61.7% women, recruited door-to-door, were assessed with the Portuguese versions of T-ILS, Satisfaction With Life Scale-SWLS, Lubben Social Network Scale 6-items-LSNS-6, a question regarding Happiness/Unhappiness, and a sociodemographic questionnaire. The T-ILS showed good psychometric properties and correlated moderately with SWLS and LSNS-6, and happiness, and weakly with the number of people in the household. The Portuguese version of the T-ILS proved to be a valid and reliable instrument, easy and quick to administer. It proved to be a valuable tool in screening loneliness in Portugal, being potentially useful to the identification of lonelier people in need of intervention.

Does emotional dysregulation mediate the relationship between disability and depressive symptoms in older people? / ¿La desregulación emocional media la relación entre la discapacidad y los síntomas depresivos en las personas mayores?

Background: Emotion dysregulation has been consistently linked to psychopathology, and the relationship between disability and depressive symptomatology in old age is well-known. Objective: To examine the mediational role of emotional dysregulation in the relationship between perceived disability and depressive symptomatology in older adults. Methods: Two hundred eighty-three participants, aged 60–96 years (M±SD=74.22±8.69; 62.9% women; 29.0% with long-term care support [LTC-S] and 71.0% community residents without LTC-S), were assessed with the Geriatric Depression Scale-8 (GDS-8), the World Health Organization Disability Assessment Schedule-2 (WHODAS-2), and the Difficulties in Emotion Regulation Scale-16 (DERS-16). Results: A mediation model was established, which revealed: (1) a moderate association between WHODAS-2 and GDS-8 (β=0.20; p<.001); (2) DERS-16 partially and weakly mediated the relationship between WHODAS-2 and GDS-8 (β=0.003; p<.01). The model explained 31.9% of the variance of depressive symptoms. An inconsistent mediation model was obtained in the LTC-S group. Conclusions: Globally, our findings indicate that disability has an indirect relationship with depressive symptomatology through emotional dysregulation (except for those in the LTC-S). Accordingly, we present suggestions for the treatment of depressive symptoms and for the inclusion of other emotion regulation variables in the study of the disability-depressive symptom link in future studies with older people in the LTC-S. (AU)

Antecedentes: La desregulación de las emociones se ha relacionado sistemáticamente con la psicopatología, y es bien conocida la relación entre la discapacidad y la sintomatología depresiva en la edad avanzada. Objetivo: Examinar el papel mediador de la desregulación emocional en la relación entre la discapacidad percibida y la sintomatología depresiva en los adultos mayores. Materiales y métodos: Doscientos ochenta y tres participantes, entre 60-96 años de edad (M±DE=74,22±8,69; 62,9% mujeres; 29% con apoyo de cuidados de larga duración [A-CLD] y 71% residentes en la comunidad sin A-CLD), fueron evaluados con la Geriatric Depression Scale-8 (GDS-8), el World Health Organization Disability Assessment Schedule-2 (WHODAS-2) y la Difficulties in Emotion Regulation Scale-16 (DERS-16). Resultados: Se estableció un modelo de mediación que reveló: (1) una asociación moderada entre el WHODAS-2 y el GDS-8 (β=0,20; p<0,001); (2) el DERS-16 medió parcial y ligeramente la relación entre el WHODAS-2 y el GDS-8 (β=0,003; p<0,01). El modelo explicó el 31,9% de la varianza de los síntomas depresivos. Se ha obtenido un modelo de mediación inconsistente en el grupo A-CLD. Conclusiones: Globalmente, nuestros hallazgos indican que la discapacidad tiene una relación indirecta con la sintomatología depresiva a través de la desregulación emocional. En consecuencia, presentamos sugerencias para el tratamiento de los síntomas depresivos y para la inclusión de otras variables de regulación de las emociones en el estudio del vínculo discapacidad-síntomas depresivos en futuros estudios con personas mayores en el A-CLD. (AU)

Does emotional dysregulation mediate the relationship between disability and depressive symptoms in older people?

BACKGROUND: Emotion dysregulation has been consistently linked to psychopathology, and the relationship between disability and depressive symptomatology in old age is well-known. OBJECTIVE: To examine the mediational role of emotional dysregulation in the relationship between perceived disability and depressive symptomatology in older adults. METHODS: Two hundred eighty-three participants, aged 60-96 years (M±SD=74.22±8.69; 62.9% women; 29.0% with long-term care support [LTC-S] and 71.0% community residents without LTC-S), were assessed with the Geriatric Depression Scale-8 (GDS-8), the World Health Organization Disability Assessment Schedule-2 (WHODAS-2), and the Difficulties in Emotion Regulation Scale-16 (DERS-16). RESULTS: A mediation model was established, which revealed: (1) a moderate association between WHODAS-2 and GDS-8 (ß=0.20; p<.001); (2) DERS-16 partially and weakly mediated the relationship between WHODAS-2 and GDS-8 (ß=0.003; p<.01). The model explained 31.9% of the variance of depressive symptoms. An inconsistent mediation model was obtained in the LTC-S group. CONCLUSIONS: Globally, our findings indicate that disability has an indirect relationship with depressive symptomatology through emotional dysregulation (except for those in the LTC-S). Accordingly, we present suggestions for the treatment of depressive symptoms and for the inclusion of other emotion regulation variables in the study of the disability-depressive symptom link in future studies with older people in the LTC-S.

Validation of the geriatric sleep questionnaire.

OBJECTIVE: Assessing sleep in later life is essential for diagnosing and treating sleep problems and their consequences. We aimed to test a short questionnaire specifically designed to assess the subjective sleep quality in older people, the Geriatric Sleep Questionnaire (GSQ). METHOD: The GSQ was validated in a Portuguese sample of older people (N = 443; 65-100 years; M = 80.02; SD = 6.95). We analyzed reliability, factor validity, convergent validity with other theoretical similar constructs, discriminant validity with a theoretically divergent measure, and predictive power to detect sleep problems (ROC analysis). RESULTS: A six-item version was obtained with good reliability (Cronbach's α = 0.79), and adequate convergent and divergent validity (p < 0.01). ROC analysis revealed a sensitivity of 80.0% and a specificity of 66.7% in detecting sleep problems with a cutoff point of 16 (AUC = 0.72). Older people in social care, low education, and living in rural areas reported worse sleep quality. CONCLUSION: The GSQ-6 is a brief instrument with good psychometric characteristics to assess the subjective sleep quality in older people. The GSQ-6 seems to be a valuable tool for future investigations on the relationship of sleep quality with mental health and well-being in older people.

Validity and reliability of a shorter version of the Geriatric Depression Scale in institutionalized older Portuguese adults.

OBJECTIVES: Depressive symptoms are common in older adults in institutional contexts; however, there is a lack of validated measures for these settings. Identifying depressive symptoms can help clinicians to manage them and to prevent or delay their complications. This study aimed to validate the Geriatric Depression Scale (GDS) in an institutionalized sample of older adults. METHOD: 493 institutionalized older people (73% women) aged 60 or over were evaluated through the GDS, the Mini International Neuropsychiatric Interview (MINI) (depression vs. no depression = 11% vs. 89%), the Geriatric Anxiety Inventory (GAI), the Positive Affect (PA) and Negative Affect (NA) Schedule, and the Satisfaction with Life Scale (SWLS). Test-retest reliability was assessed with 57 older adults. RESULTS: An 8-item version presented a Cronbach's alpha value of .87 with a single factor explaining its variance. The correlations (p < .01) attested the concurrent validity (GAI: r = .76; PA: r = -.22; AN: r = .62; SWLS: r = -.32). Test-retest reliability (6.51 months) was adequate (r = .52). ROC analysis (AUC = .82; sensitivity = 80%; specificity = 77%) and Youden index revealed a cutoff of 5/6 for the diagnosis of depression. CONCLUSION: Results support the validity and the screening capacity of a short version of GDS in institutional contexts. Short screening instruments for depressive symptoms may facilitate their identification, allowing for timely clinical interventions in institutional settings.

The language aspects of children with high abilities/giftedness: an integrative literature review / Os aspectos da linguagem de crianças com altas habilidades/superdotação: revisão integrativa da literatura

ABSTRACT Purpose: to analyze information and characteristics of the language of children diagnosed with high abilities and giftedness. Methods: an integrative literature review based on a search in LILACS, MEDLINE, and Google Scholar databases, combining the keywords "Speech-Language-Hearing and high abilities", "giftedness and child language". Results: a total of 45 articles that met the inclusion criteria were analyzed, of which 29 were excluded and 16 selected for the review. The analysis of these articles made it possible to verify, though superficially, the aspects in the oral and written language of children with high abilities and giftedness. These children's vocabulary and discourse are usually rich, with excellent comprehension skills. There is early interest in reading, besides noteworthy writing comprehension and decoding skills. The studies indicate that these capacities are atypical when compared with those of the population referred to as normal. The discourse of gifted children tends to be compatible with that of children two years older, and their language develops faster. Conclusion: the language of children diagnosed with high abilities and giftedness has particularities that must be better studied, as their development differs from that of other children.

RESUMO Objetivo: analisar informações e características sobre a linguagem de crianças com diagnóstico para altas habilidades e superdotação. Métodos: revisão integrativa da literatura realizada a partir da busca de dados em bases eletrônicas do Portal de Pesquisas da Biblioteca Virtual em Saúde, LILACS, MEDLINE, Google Scholar, utilizando combinação das palavras chaves "Fonoaudiologia e altas habilidades", "superdotação e linguagem infantil". Resultados: foram analisados 45 artigos que preencheram os critérios de inclusão, dentre os quais 29 foram excluídos e 16 selecionados para a revisão. A análise destes artigos permitiu verificar, ainda que superficialmente, os aspectos presentes na linguagem oral e escrita de crianças com altas habilidades e superdotação. O vocabulário e discurso destas crianças geralmente é rico, com excelente habilidade de compreensão. Há um interesse precoce pela leitura, além de notável habilidade de decodificação e compreensão da escrita. Os estudos indicam que, estas capacidades se apresentam de uma maneira atípica, quando comparadas a população tida como normal, cujo discurso tende a ser compatível com crianças 2 anos mais velhas e o desenvolvimento da linguagem ocorrendo de maneira mais acelerada. Conclusão: a linguagem das crianças diagnosticadas com altas habilidades e superdotação possui particularidades que devem ser melhor estudadas, pois o seu desenvolvimento se difere das demais crianças.

Avaliação dos níveis de albuminúria em adultos obesos e sua associação com marcadores de risco cardiovascular / Albuminuria levels in obese adults and their association with cardiovascular risk markers

Introdução: A obesidade é um dos fatores mais importantes para explicar o aumento incidência das Doenças Cardiovasculares (DCV). Dentre os múltiplos fatores de risco para estas doenças, a albuminúria é dos mais importantes. Objetivos: Avaliar os níveis de albuminúria e correlacionar com outros marcadores de risco cardiovascular em pacientes obesos que procuraram tratamento para obesidade. Materiais e métodos:Estudo transversal, retrospectivo, através dos prontuários de 183 pacientes de ambos os sexos, entre 18 e 65 anos, com índice de massa corpórea (IMC) ≥ 30 Kg/m². Todos os pacientes foram submetidos a exame físico e receberam um pedido de rotina laboratorial, incluindo de albuminúria em amostra isolada de urina. Valores até 17 mg/L foram considerados normoalbuminúria, de 17-173 mg/L microalbuminuria e ≥ 174mg/L macroalbuminúria. A análise de correlação de Pearson ou Spearman foi utilizada para correlacionar os níveis de albuminuria com as variáveis antropométricas e laboratoriais. Resultados: Dados de albuminúria estavam disponíveis em 81 prontuários. Destes, 15 pacientes (18,5%) tinham valores acima de 17 mg/L de albuminúria. Nenhuma correlação foi encontrada entre os níveis de albuminúria e os parâmetros antropométricos (IMC, Cintura, Quadril e RCQ), pressão arterial (PA) sistólica ou diastólica ou uso de anti-hipertensivos. Foi encontrada correlação entre os níveis de albuminúria e o high-density lipoprotein cholesterol (HDLc), (r=-0,27; p=0,012), além de uma tendência a significância com os níveis de Proteína C Reativa Ultrassensível (PCR-us; r=0,21; p= 0,081). Conclusão: Apesar da alta frequência de albuminúria em pacientes obesos, não foi encontrada correlação entre este marcador e os parâmetros antropométricos. Foi encontrado uma relação inversa da albuminúria com HDLc e uma tendência a significância com a PCR-us, sugerindo uma associação limitada entre a albuminúria e alguns marcadores específicos de risco cardiovascular.

Introduction: Obesity is one of the most important factors related to the increase in Cardiovascular Diseases (CVD) incidence. Among all risk factors for CVD, albuminuria is one of the most relevant. Objective:To evaluate the levels of albuminuria and to correlate with other cardiovascular risk markers in obese patients who seek treatment for obesity. Material and Methods: A retrospective cross-sectional study of 183 patients of both genders, aged 18-65 years, with a body mass index (BMI) ≥ 30 kg / m², attended for the first time. All the patients were submitted to a physical exam and received a routine laboratory request, including for the concentration of albumin in the urine. Values below 17 mg/L were considered normoalbuminuria, from 17 to 173 mg/dL microalbuminuria and above 174 macroalbuminuria. Pearson ou Spearman Correlation was used to correlate albuminuria levels with anthropometric and laboratorial variables. Results: Excluding 102 patient charts out of the criteria, the results of 81 patients were considered. Of these, 15 patients (18.5%) had values above 17 mg / L of albuminuria. No correlation was found between albuminuria levels and anthropometric parameters (BMI, Waist, Hip), systolic BP, diastolic BP or antihypertensive use. A significant correlation was found between albuminuria levels and high-density lipoprotein cholesterol (HDLc), (r = -0.27, p = 0.012), and a trend toward significance with hs-CRP levels (r = 0, 21, p = 0.081). Conclusion: Despite the high prevalence of albuminuria in obese patients, no correlation was found between anthropometric markers and albuminuria. An inverse relationship was found for albuminuria with HDLc, and a trend toward significance with hs-CRP, suggesting a limited association between albuminuria and some specific markers of cardiovascular risk.

Estudo longitudinal dos fatores associados à evolução de sintomas depressivos em idosos institucionalizados / Longitudinal study of factors associated with the development of depressive symptoms in institutionalized elderly

Objetivos : Constatando que a depressão é comum em idosos institucionalizados, associando-se à solidão, à ansiedade e à afetividade, pretendemos descrever a evolução da depressão durante dois anos e verificar que fatores se associam a essa evolução. Métodos : Em um estudo de coorte prospectivo em dois momentos (2011 e 2013), avaliamos 83 idosos institucionalizados, com idade no primeiro momento entre os 60 e os 100 anos, sendo 79,5% mulheres, 86,7% sem companheiro(a), e 72,3% com algum grau de escolaridade. Usamos a Escala Geriátrica da Depressão (GDS), a Escala de Solidão (UCLA-L), o Inventário Geriátrico de Ansiedade (GAI) e a Lista de Afetos Positivos e Negativos (PANAS). Resultados: Verificamos que 59,0% mantiveram a depressão e 10,8% desenvolveram depressão. Os idosos com depressão tiveram significativamente piores resultados na UCLA, GAI e PANAS, e os não depressivos tiveram afetos positivos mais altos. Quanto à evolução da depressão, os idosos que mantiveram depressão tiveram inicialmente pontuações elevadas no GDS, GAI, UCLA e na subescala PANAS negativo e pontuações baixas na subescala PANAS positivo. Esses idosos apresentaram associadamente um agravamento dos sentimentos de solidão, dos sintomas ansiosos e do afeto negativo ao longo dos dois anos. Os que desenvolveram depressão tiveram, no primeiro momento, pontuações elevadas na UCLA. Conclusões: Os sintomas de depressão com ou sem solidão no momento inicial, o agravamento da solidão, a ansiedade, o afeto negativo e o baixo afeto positivo poderão ser fatores de risco para a manutenção da depressão. A solidão poderá ainda ser um fator de risco para o desenvolvimento de depressão. .

Objectives : Knowing that depression is common in institutionalized elderly and associated with loneliness, anxiety, and affectivity, we want to describe the evolution of depression over two years and identify which factors are associated with the development of depression. Methods: In this prospective cohort study, that encompassed two evaluation moments (2011 and 2013), 83 institutionalized elders were inquired, with age at baseline between 60 and 100 years, 79.5% women, 86.7% single and 72.3% with some type of education. The instruments included the Geriatric Depression Scale (GDS), Loneliness Scale (UCLA-L), Geriatric Anxiety Inventory (GAI) and List of Positive and Negative Affects (PANAS). Results: Fifty-nine percent of the subjects maintained depression, and 10.8% developed depression. Elderly patients with depression had significantly worse outcomes in the UCLA, GAI and PANAS, and those who were not depressed had a higher positive affect. Regarding the evolution of depression, elders that maintained depression had high scores on the GDS, GAI, UCLA, and negative PANAS subscale, and low scores on the PANAS positive subscale at baseline. These elders showed an increase in the feelings of loneliness, anxiety symptoms, and negative affect over the two years. Those who developed depression had higher scores on the UCLA-L at baseline. Conclusions: We conclude that depression symptoms with or without loneliness at baseline, the worsening of loneliness, anxiety, and of the positive and negative affects may all be risk factors for the maintenance of depression. Loneliness may also be a risk factor for the development of depression. .